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Sloth Hair as a Novel Source of Fungi with Potent Anti-Parasitic, Anti-Cancer and Anti-Bacterial Bioactivity

Overview of attention for article published in PLoS ONE, January 2014
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
6 news outlets
blogs
9 blogs
twitter
221 tweeters
facebook
89 Facebook pages
googleplus
15 Google+ users
reddit
6 Redditors
video
1 video uploader

Citations

dimensions_citation
10 Dimensions

Readers on

mendeley
110 Mendeley
Title
Sloth Hair as a Novel Source of Fungi with Potent Anti-Parasitic, Anti-Cancer and Anti-Bacterial Bioactivity
Published in
PLoS ONE, January 2014
DOI 10.1371/journal.pone.0084549
Pubmed ID
Authors

Sarah Higginbotham, Weng Ruh Wong, Roger G. Linington, Carmenza Spadafora, Liliana Iturrado, A. Elizabeth Arnold

Abstract

The extraordinary biological diversity of tropical forests harbors a rich chemical diversity with enormous potential as a source of novel bioactive compounds. Of particular interest are new environments for microbial discovery. Sloths--arboreal mammals commonly found in the lowland forests of Panama--carry a wide variety of micro- and macro-organisms on their coarse outer hair. Here we report for the first time the isolation of diverse and bioactive strains of fungi from sloth hair, and their taxonomic placement. Eighty-four isolates of fungi were obtained in culture from the surface of hair that was collected from living three-toed sloths (Bradypus variegatus, Bradypodidae) in Soberanía National Park, Republic of Panama. Phylogenetic analyses revealed a diverse group of Ascomycota belonging to 28 distinct operational taxonomic units (OTUs), several of which are divergent from previously known taxa. Seventy-four isolates were cultivated in liquid broth and crude extracts were tested for bioactivity in vitro. We found a broad range of activities against strains of the parasites that cause malaria (Plasmodium falciparum) and Chagas disease (Trypanosoma cruzi), and against the human breast cancer cell line MCF-7. Fifty fungal extracts were tested for antibacterial activity in a new antibiotic profile screen called BioMAP; of these, 20 were active against at least one bacterial strain, and one had an unusual pattern of bioactivity against Gram-negative bacteria that suggests a potentially new mode of action. Together our results reveal the importance of exploring novel environments for bioactive fungi, and demonstrate for the first time the taxonomic composition and bioactivity of fungi from sloth hair.

Twitter Demographics

The data shown below were collected from the profiles of 221 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 110 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 4%
United Kingdom 2 2%
Brazil 1 <1%
India 1 <1%
Belgium 1 <1%
Canada 1 <1%
Unknown 100 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 30 27%
Student > Bachelor 21 19%
Researcher 17 15%
Other 12 11%
Student > Master 8 7%
Other 22 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 64 58%
Biochemistry, Genetics and Molecular Biology 7 6%
Medicine and Dentistry 7 6%
Unspecified 5 5%
Environmental Science 5 5%
Other 22 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 324. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 May 2019.
All research outputs
#33,300
of 12,980,369 outputs
Outputs from PLoS ONE
#728
of 140,156 outputs
Outputs of similar age
#643
of 286,369 outputs
Outputs of similar age from PLoS ONE
#39
of 7,941 outputs
Altmetric has tracked 12,980,369 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 140,156 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.9. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 286,369 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 7,941 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.